NK1 receptor (nk1r_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Tachykinin receptors NK1 receptor
GENE
TACR1 (NK1R, TAC1R)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Substance-P receptor, SPR, NK-1 receptor, NK-1R, Tachykinin receptor 1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
N
|
V
|
L
|
P
|
V
|
D
|
S
|
D
|
10 |
L
|
S
|
P
|
N
|
I
|
S
|
T
|
N
|
T
|
S
|
20 |
TM1 | |||||||||
E
|
P
|
N
|
Q
|
F
|
V
|
Q
|
P
|
A
|
W
|
30 |
Q
|
I
|
V
|
L
|
W
|
A
|
A
|
A
|
Y
|
T
|
40 |
V
|
I
|
V
|
V
|
T
|
S
|
V
|
V
|
G
|
N
|
50 |
V
|
V
|
V
|
M
|
W
|
I
|
I
|
L
|
A
|
H
|
60 |
ICL1 | TM2 | ||||||||
K
|
R
|
M
|
R
|
T
|
V
|
T
|
N
|
Y
|
F
|
70 |
L
|
V
|
N
|
L
|
A
|
F
|
A
|
E
|
A
|
S
|
80 |
M
|
A
|
A
|
F
|
N
|
T
|
V
|
V
|
N
|
F
|
90 |
ECL1 | |||||||||
T
|
Y
|
A
|
V
|
H
|
N
|
E
|
W
|
Y
|
Y
|
100 |
TM3 | |||||||||
G
|
L
|
F
|
Y
|
C
|
K
|
F
|
H
|
N
|
F
|
110 |
F
|
P
|
I
|
A
|
A
|
V
|
F
|
A
|
S
|
I
|
120 |
Y
|
S
|
M
|
T
|
A
|
V
|
A
|
F
|
D
|
R
|
130 |
ICL2 | |||||||||
Y
|
M
|
A
|
I
|
I
|
H
|
P
|
L
|
Q
|
P
|
140 |
TM4 | |||||||||
R
|
L
|
S
|
A
|
T
|
A
|
T
|
K
|
V
|
V
|
150 |
I
|
C
|
V
|
I
|
W
|
V
|
L
|
A
|
L
|
L
|
160 |
L
|
A
|
F
|
P
|
Q
|
G
|
Y
|
Y
|
S
|
T
|
170 |
ECL2 | |||||||||
T
|
E
|
T
|
M
|
P
|
S
|
R
|
V
|
V
|
C
|
180 |
TM5 | |||||||||
M
|
I
|
E
|
W
|
P
|
E
|
H
|
P
|
N
|
K
|
190 |
I
|
Y
|
E
|
K
|
V
|
Y
|
H
|
I
|
C
|
V
|
200 |
T
|
V
|
L
|
I
|
Y
|
F
|
L
|
P
|
L
|
L
|
210 |
V
|
I
|
G
|
Y
|
A
|
Y
|
T
|
V
|
V
|
G
|
220 |
I
|
T
|
L
|
W
|
A
|
S
|
E
|
I
|
P
|
G
|
230 |
ICL3 | TM6 | ||||||||
D
|
S
|
S
|
D
|
R
|
Y
|
H
|
E
|
Q
|
V
|
240 |
S
|
A
|
K
|
R
|
K
|
V
|
V
|
K
|
M
|
M
|
250 |
I
|
V
|
V
|
V
|
C
|
T
|
F
|
A
|
I
|
C
|
260 |
W
|
L
|
P
|
F
|
H
|
I
|
F
|
F
|
L
|
L
|
270 |
ECL3 | |||||||||
P
|
Y
|
I
|
N
|
P
|
D
|
L
|
Y
|
L
|
K
|
280 |
TM7 | |||||||||
K
|
F
|
I
|
Q
|
Q
|
V
|
Y
|
L
|
A
|
I
|
290 |
M
|
W
|
L
|
A
|
M
|
S
|
S
|
T
|
M
|
Y
|
300 |
H8 | |||||||||
N
|
P
|
I
|
I
|
Y
|
C
|
C
|
L
|
N
|
D
|
310 |
R
|
F
|
R
|
L
|
G
|
F
|
K
|
H
|
A
|
F
|
320 |
C-term | |||||||||
R
|
C
|
C
|
P
|
F
|
I
|
S
|
A
|
G
|
D
|
330 |
Y
|
E
|
G
|
L
|
E
|
M
|
K
|
S
|
T
|
R
|
340 |
Y
|
L
|
Q
|
T
|
Q
|
G
|
S
|
V
|
Y
|
K
|
350 |
V
|
S
|
R
|
L
|
E
|
T
|
T
|
I
|
S
|
T
|
360 |
V
|
V
|
G
|
A
|
H
|
E
|
E
|
E
|
P
|
E
|
370 |
D
|
G
|
P
|
K
|
A
|
T
|
P
|
S
|
S
|
L
|
380 |
D
|
L
|
T
|
S
|
N
|
C
|
S
|
S
|
R
|
S
|
390 |
D
|
S
|
K
|
T
|
M
|
T
|
E
|
S
|
F
|
S
|
400 |
F
|
S
|
S
|
N
|
V
|
L
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
neuropeptide-γ, hemokinin 1, neurokinin A, neuropeptide K, neurokinin B, substance P